Recombinant Human Mitochondrial Fission 1 Protein/FIS1 Protein (His Tag)

Product Specifications

Background

Mitochondrial Fission 1 Protein (FIS1) is a member of the FIS1 family. FIS1 is a single-pass membrane protein and contains one TPR repeat. FIS1 is part of the mitochondrial complex that promotes mitochondrial fission. FIS1 can induce cytochrome C discharge from the mitochondrion to the cytosol, eventually leading to apoptosis. In addition, FIS1 participates in peroxisomal growth and division. The C-terminus of FIS1 is required for mitochondrial or peroxisomal localization, while the N-terminus is necessary for mitochondrial or peroxisomal fission, localization and regulation of the interaction with DNM1L.

Abbreviation

Mitochondrial Fission 1; FIS1

Synonyms

CGI-135; FIS1; FIS1 Homolog; Mitochondrial Fission 1 Protein; TPR Repeat Protein 11; TTC11; Tetratricopeptide Repeat Protein 11; hFis1

UniProt

Q9Y3D6

Accession Number

Q9Y3D6

Expression System

E.coli

Tag

C-His

Sequence

Met 1-Gly122

Field of Research

Cell biology; Cancer; metabolism

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.