Recombinant Human LDH-A/LDHA Protein (His Tag)
Product Specifications
Background
L-Lactate Dehydrogenase A Chain (LDHA) is an enzyme that catalyzes the conversion of L-lactate and NAD+ to pyruvate and NADH in the final step of anaerobic glycolysis. LDHA contains an N-terminal coenzyme binding region, a central catalytic site, and at least nine utilized Lys acetylation and two Tyr phosphorylation sites. LDHA belongs to the lactate dehydrogenase family, expressed predominantly in muscle tissue. LDHA mutations have been linked to exertional myoglobinuria.
Abbreviation
LDH-A; LDHA
Synonyms
Cell Proliferation-Inducing Gene 19 Protein; L-Lactate Dehydrogenase A Chain; LDH Muscle Subunit; LDH-A; LDH-M; LDHA; Renal Carcinoma Antigen NY-REN-59
UniProt
P00338
Accession Number
P00338
Expression System
E.coli
Tag
N-His
Sequence
Met 1-Phe332
Field of Research
Signal Transduction; Cancer; metabolism
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Product Datasheet
https://789.bio/ea/yeymdo
Product MSDS
https://789.bio/eb/DC0qj5
Calculated Molecular Weight
38.8 kDa
Observed Molecular Weight
37 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 500mM NaCl, 5% Trehalose, 5% Mannitol, 0.01% Tween 80, 1mM EDTA, 50% Glycerol, pH8.0.
Species
Human
Available Sizes
Curated Selection
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