Recombinant Human CD47/IAP Protein (Fc Tag)
Product Specifications
Background
CD47 (Integrin-Associated Protein; IAP) is a 40 - 60 kDa variably glycosylated atypical member of the immunoglobulin superfamily. The ubiquitously expressed CD47 binds to SIRP family members on macrophages; neutrophils; and T cells. CD47 is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The protein is also a receptor for the C-terminal cell-binding domain of thrombospondin; and it may play a role in membrane transport and signal transduction. This protein has broad tissue distribution; and is reduced in expression on Rh erythrocytes.
Abbreviation
CD47; IAP
Synonyms
Antigenic Surface Determinant Protein OA3; CD47; IAP; Integrin-Associated Protein; Leukocyte Surface Antigen CD47; MER6; Protein MER6
UniProt
Q08722
Accession Number
Q08722
Expression System
HEK293 Cells
Tag
C-Fc
Sequence
Gln19-Pro139
Field of Research
Cancer; immunology
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/pl9kvs
Product MSDS
https://789.bio/eb/9Su5qH
Calculated Molecular Weight
40.9 kDa
Observed Molecular Weight
60 kDa
Species
Human
Available Sizes
Curated Selection
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