Recombinant Human Ketohexokinase/KHK Protein (His Tag)
Product Specifications
Background
Ketohexokinase, also known as Hepatic fructokinase, is a member of the carbohydrate kinase PfkB family. It exits as a homodimer and most abundant in liver, kidney, gut, spleen and pancreas. Low levels also found in adrenal, muscle, brain and eye.This enzyme catalyzes conversion of fructose to fructose-1-phosphate. It is the first enzyme with a specialized pathway that catabolizes dietary fructose. Defects in KHK are the cause of fructosuria.
Abbreviation
Ketohexokinase; KHK
Synonyms
Hepatic fructokinase; KHK; Ketohexokinase
UniProt
P50053
Accession Number
AAH06233.1
Expression System
HEK293 Cells
Tag
C-His
Sequence
Met 1-Val298
Field of Research
Signal Transduction; Cancer; metabolism
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
33.7 kDa
Observed Molecular Weight
30 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 50nM KCl, 10% Glycerol, pH 7.4.
Species
Human
Available Sizes
Documents
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