Recombinant Human KPNA2 Protein (His Tag)
Product Specifications
Background
Karyopherin Subunit α-2 (KPNA2) belongs to the importin alpha family. KPNA2 is widely expressed in many tissues and contains an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. KPNA2 interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V (D) J recombination. KPNA2 functions in nuclear protein importantly as an adapter protein for nuclear receptor KPNB1.
Abbreviation
KPNA2
Synonyms
Importin Subunit Alpha-2; KPNA2; Karyopherin Subunit Alpha-2; RAG Cohort Protein 1; RCH1; SRP1; SRP1-Alpha
UniProt
P52292
Accession Number
P52292
Expression System
E.coli
Tag
N-His
Sequence
Met 1-Phe529
Field of Research
Signal Transduction; immunology
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
60.0 kDa
Observed Molecular Weight
46-63 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 1mM DTT, 20% Glycerol, pH 8.0.
Species
Human
Available Sizes
Documents
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