Recombinant Human Kallikrein 2/KLK2 Protein (His Tag)
Product Specifications
Background
Kallikrein-2 (KLK2) is a secreted serine protease that belongs to the peptidase S1 family of Kallikrein subfamily. KLK2 contains 1 peptidase S1 domain. It is highly expressed in the human prostate gland. KLK2 can cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin, but Preferential cleavages of Arg-|-Xaa bonds in small molecule substrates. It also highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa. KLK2 is inhibited by serpins such as protein C inhibitor, antichymotrypsin, and plasminogen. KLK2 is considered to be a biomarker for prostate cancer.
Abbreviation
Kallikrein 2; KLK2
Synonyms
Glandular Kallikrein-1; KLK2; Kallikrein-2; Tissue Kallikrein-2; hGK-1
UniProt
P20151
Accession Number
P20151
Expression System
HEK293 Cells
Tag
C-His
Sequence
Pro19-Pro261
Field of Research
Signal Transduction; Cell biology; Cancer
Endotoxin
< 0.01 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
27.9 kDa
Observed Molecular Weight
10-12&16-19&28-33 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM Acetate, 250mM Trehalose, 0.02% Tween 80, pH5.0.
Species
Human
Available Sizes
Curated Selection
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