Recombinant Human Kallikrein 1/KLK1 Protein (His Tag)
Product Specifications
Background
Kallikrein-1 (KLK1) is a member of human tissue Kallikrein family. Human KLK1 precursor contains a singal peptide (residues 1 to 18), a short pro peptide (residues 19 to 24) and a mature chain (residues 25 to 262) . The function of KLK1 is to cleave Kininogen in order to release the vasoactive Kinin peptide (Lysyl-Bradykinin or Bradykinin) . The Kinin peptide controls blood pressure reduction, vasodilation, smooth muscle relaxation and contraction, pain induction and inflammation. KLK1 also plays a role in angiogensis and tumorigenesis.
Abbreviation
Kallikrein 1; KLK1
Synonyms
KLK1; Kallikrein-1; Kidney/Pancreas/Salivary Gland Kallikrein; Tissue Kallikrein
UniProt
P06870
Accession Number
AAH05313.1
Expression System
HEK293 Cells
Tag
C-His
Sequence
Pro19-Ser262
Field of Research
Signal Transduction; Cell biology; Cardiovascular; Cancer
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
28.2 kDa
Observed Molecular Weight
38-55 kDa
Formulation
2
Species
Human
Available Sizes
Curated Selection
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