Recombinant Human JAM-B/CD322 Protein (Fc Tag)

Product Specifications

Background

Junctional Adhesion Molecule B (JAM-B) is a single-pass type I membrane protein that belongs to the juctional adhesion molecules family. JAM-B includes a signal sequence (aa 1-28) ; an extracellular region (aa 29-238) with one Ig-like C2-type domain and one Ig-like V-type domain; a transmembrane segment (aa 239-259) ; and a cytoplasmic domain (aa 260 - 298) . JAMB is localized to the tight junctions between endothelial cells or epithelial cells. JAM-B is prominently expressed in the heart; placenta; lung; foreskin and lymph node. It is also present on the endothelia of other vessels. JAM-B acts as an adhesive ligand for interacting with a variety of immune cell types and may play a role in lymphocyte homing to secondary lymphoid organs.

Abbreviation

JAM-B; CD322

Synonyms

C21orf43; CD322; JAM-2; JAM-B; JAM2; Junctional Adhesion Molecule 2; Junctional Adhesion Molecule B; VE-JAM; VEJAM; Vascular Endothelial Junction-Associated Molecule

UniProt

P57087

Accession Number

P57087

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Phe29-Asn236

Field of Research

Signal Transduction; Cardiovascular

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.