Recombinant Human IPPI2/IDI2 Protein (His Tag)
Product Specifications
Background
Isopentenyl Pyrophosphate Isomerase 2 (IDI2) belongs to the IPP isomerase type 1 family. Both isozymes, IDI1 and IDI2 are localized to the peroxisome by a PTS1-dependent pathway. IDI2 is expressed in skeletal muscle, which contains one nudix hydrolase domain. IDI2 binds one magnesium per subunit. IDI2 catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) . It is reported that IDI2 is regulated independently from IDI1, by a mechanism that may involve PPAR-α.
Abbreviation
IPPI2; IDI2
Synonyms
IDI2; IPP Isomerase 2; IPPI2; Isopentenyl Pyrophosphate Isomerase 2; Isopentenyl-Diphosphate Delta-Isomerase 2
UniProt
Q9BXS1
Accession Number
Q9BXS1
Expression System
E.coli
Tag
N-His
Sequence
Met 1-Val227
Field of Research
Signal Transduction; Cardiovascular; Cancer; metabolism
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
28.9 kDa
Observed Molecular Weight
28-31 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 1mM DTT, 0.1mM PMSF, pH 8.0.
Species
Human
Available Sizes
Documents
Frequently Asked Questions
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