Recombinant Human ITM2B Protein (His Tag)
Product Specifications
Background
Integral Membrane Protein 2B (ITM2B) is expressed in the Golgi and on the cell surface. ITM2B forms homodimer through disulfide-linked interaction with SPPL2A, SPPL2B and APP. ITM2B is expressed in brain and the other tissues. Defects in ITM2B cause cerebral amyloid angiopathy ITM2B-related type 1 (CAA-ITM2B1) and amyloid angiopathy ITM2B-related type 2 (CAA-ITM2B2) . CAA-ITM2B1 is characterized by amyloid deposition in the walls of cerebral blood vessels and neurodegeneration in the central nervous system. CAA-ITM2B2 characterized by amyloid deposition in the walls of the blood vessels of the cerebrum, choroid plexus, cerebellum, spinal cord and retina.
Abbreviation
ITM2B
Synonyms
BRI; BRI2; Bri; ITM2B; Immature BRI2; Integral Membrane Protein 2B; Protein E25B; Transmembrane Protein BRI; imBRI2
UniProt
Q9Y287
Accession Number
Q9Y287
Expression System
HEK293 Cells
Tag
C-His
Sequence
Tyr76-Ser266
Field of Research
Neuroscience
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
23.3 kDa
Observed Molecular Weight
29-33 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM Acetate, 10% Trehalose, 25mM NaCl, 10% Glycerol, 0.05% Tween 80, pH 4.5.
Species
Human
Available Sizes
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