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Recombinant Human ITM2B Protein (His Tag)

Product Specifications

Background

Integral Membrane Protein 2B (ITM2B) is expressed in the Golgi and on the cell surface. ITM2B forms homodimer through disulfide-linked interaction with SPPL2A, SPPL2B and APP. ITM2B is expressed in brain and the other tissues. Defects in ITM2B cause cerebral amyloid angiopathy ITM2B-related type 1 (CAA-ITM2B1) and amyloid angiopathy ITM2B-related type 2 (CAA-ITM2B2) . CAA-ITM2B1 is characterized by amyloid deposition in the walls of cerebral blood vessels and neurodegeneration in the central nervous system. CAA-ITM2B2 characterized by amyloid deposition in the walls of the blood vessels of the cerebrum, choroid plexus, cerebellum, spinal cord and retina.

Abbreviation

ITM2B

Synonyms

BRI; BRI2; Bri; ITM2B; Immature BRI2; Integral Membrane Protein 2B; Protein E25B; Transmembrane Protein BRI; imBRI2

UniProt

Q9Y287

Accession Number

Q9Y287

Expression System

HEK293 Cells

Tag

C-His

Sequence

Tyr76-Ser266

Field of Research

Neuroscience

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

23.3 kDa

Observed Molecular Weight

29-33 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM Acetate, 10% Trehalose, 25mM NaCl, 10% Glycerol, 0.05% Tween 80, pH 4.5.

Species

Human

Available Sizes

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