Recombinant Human IGF-1/IGF1 Protein (aa 52-118)

Product Specifications

Background

Insulin-like growth factor I (IGF1) belongs to the family of insulin-like growth factors that are structurally homologous to proinsulin. Mature IGFs are generated by proteolytic processing of inactive precursor protein containing N-terminal and C-terminal propeptide regions. Mature human IGF-I consisting of 70 amino acids with 94% identity with mouse IGF1 and exhibits cross-species activity. IGF1 binds IGF-1R; IGF-2R; and the insulin receptor and plays a key role in cell cycle progression; cell proliferation and tumor progression. IGF1 expression is regulated by growth hormone.

Abbreviation

IGF-1; IGF1

Synonyms

IBP1; IGF-I; IGF1; Insulin-Like Growth Factor I; MGF; Mechano Growth Factor; Somatomedin-C

UniProt

P05019

Accession Number

P05019

Expression System

E.coli

Tag

None

Sequence

Thr52-Ala118

Applications

Cell culture

Field of Research

Signal Transduction; Cancer; Developmental Biology

Endotoxin

< 0.5 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.