Recombinant Human IMPA2/IMPase 2 Protein (His Tag)
Product Specifications
Background
Inositol monophosphatase 2, also known as Inositol-1 (or 4) -monophosphatase 2, Myo-inositol monophosphatase A2 and IMPA2, is an enzyme which belongs to the inositol monophosphatase family. IMPA2 catalyzes the dephosphoylration of inositol monophosphate with cofactor Magnesium and Inhibited by high Li+ and restricted Mg2+ concentrations. IMPA2 plays an important role in phosphatidylinositol signaling. IMPA2 can use the myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. IMPA2 is a pharmacological target for lithium Li (+) action in brain, it is considered to have a role in schizophrenia and bipolar disorder.
Abbreviation
IMPA2; IMPase 2
Synonyms
IMP 2; IMP.18P; IMPA2; IMPase 2; Inositol Monophosphatase 2; Inositol-1 (or 4) -Monophosphatase 2; Myo-Inositol Monophosphatase A2
UniProt
O14732
Accession Number
O14732
Expression System
E.coli
Tag
N-His
Sequence
Met 1-Lys288
Field of Research
Signal Transduction; Neuroscience; Cancer; metabolism
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
33.5 kDa
Observed Molecular Weight
30 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 2mM DTT, pH 8.0.
Species
Human
Available Sizes
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