Recombinant Human IGF2BP2 Protein (His Tag, N-T7 Tag)

Product Specifications

Background

Insulin-Like Growth Factor 2 mRNA-Binding Protein 2 (IGFBP2) belongs to the RRM IMP/VICKZ family. IGFBP2 is a cytoplasmic protein and contains four KH domains and two RRM (RNA recognition motif) domains. IGF2BP2 binds to the 5'-UTR of the Insulin-Like Growth Factor 2 (IGF2) mRNA. This binding is isoform-specific. IGF2BP2 may regulate translation of target mRNAs. Genetic variation at the IGF2BP2 gene has been associated with type 2 diabetes (T2D) by genome-wide association studies and by replication analyses.

Abbreviation

IGF2BP2

Synonyms

Hepatocellular Carcinoma Autoantigen p62; IGF-II mRNA-Binding Protein 2; IGF2 mRNA-Binding Protein 2; IGF2BP2; IMP-2; IMP2; Insulin-Like Growth Factor 2 mRNA-Binding Protein 2; VICKZ Family Member 2; VICKZ2

UniProt

Q9Y6M1

Accession Number

Q9Y6M1

Expression System

E.coli

Tag

N-T7 & C-His

Sequence

Met 1-Thr 220

Field of Research

Signal Transduction; epigenetics and nuclear signal; immunology; metabolism

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.