Recombinant Human Hyaluronidase-1/HYAL1 Protein (His Tag)
Product Specifications
Background
Hyaluronidase-1 (HYAL1) is a secreted lysosomal hyaluronidase that belongs to the glycosyl hydrolase 56 family. HYAL1 contains one EGF-like domain and is highly expressed in the liver, kidney, and heart, but it is weakly expressed in the lung, placenta, and skeletal muscle. HYAL1 is thought to be involved in cell proliferation, migration, and differentiation. It may play a role in promoting tumor progression and blocking the TGFB1-enhanced cell growth. Mutations in HYAL1 are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency.
Abbreviation
Hyaluronidase-1; HYAL1
Synonyms
HYAL1; Hyal-1; Hyaluronidase-1; Hyaluronoglucosaminidase-1; LUCA1; LuCa-1; Lung Carcinoma Protein 1
UniProt
Q12794
Accession Number
Q12794
Expression System
HEK293 Cells
Tag
C-His
Sequence
Phe22-Trp435
Field of Research
Signal Transduction; Cancer
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
47.2 kDa
Observed Molecular Weight
50-65 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH 7.5.
Species
Human
Available Sizes
Documents
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