Recombinant Human Hepcidin/HAMP Protein (GST Tag)
Product Specifications
Background
Hepcidin (HAMP) is a secreted protein that belongs to the hepcidin family.It is expressed in liver, heart and brain. It is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta sheet structures.
Abbreviation
Hepcidin; HAMP
Synonyms
HEPC; LEAP1; Liver-expressed antimicrobial peptide 1; Putative liver tumor regressor
UniProt
P81172
Accession Number
P81172
Expression System
E.coli
Tag
N-GST
Sequence
Asp60-Thr84
Field of Research
Signal Transduction; Cardiovascular; Cancer; metabolism
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 85 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
29.2 kDa
Observed Molecular Weight
28-30 kDa
Formulation
Supplied as a 0.2 μm filtered solution of PBS, 50% Glycerol, pH 7.4.
Species
Human
Available Sizes
Documents
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