Recombinant Human HPGDS/GSTS Protein
Product Specifications
Background
Hematopoietic Prostaglandin D Synthase (HPGDS) belongs to the GST superfamily and Sigma family. HPGDS contains one GST C-terminal domain and one GST N-terminal domain. HPGDS is highly expressed in adipose tissue, macrophages, and placenta, and it exists in the form of homodimer in living body. HPGDS is a cytosolic enzyme that isomerizes PGH (2) . HPGDS is a bifunctional enzyme that catalyzes both the conversion of PGH2 to PGD2 and also shows low glutathione-peroxidase activity towards cumenehydroperoxide.
Abbreviation
HPGDS; GSTS
Synonyms
GST Class-Sigma; GSTS; Glutathione S-Transferase; Glutathione-Dependent PGD Synthase; Glutathione-Requiring Prostaglandin D Synthase; H-PGDS; HPGDS; Hematopoietic Prostaglandin D Synthase; PGDS; PTGDS2; Prostaglandin-H2 D-Isomerase
UniProt
O60760
Accession Number
O60760
Expression System
E.coli
Tag
None
Sequence
Met 1-Leu199
Field of Research
Signal Transduction
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
22.3 kDa
Observed Molecular Weight
26 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 200mM NaCl, pH 7.0.
Species
Human
Available Sizes
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