Recombinant Human HSPB8 Protein (His Tag)
Product Specifications
Background
Heat shock protein beta-8 (HSPB8) belongs to the small heat shock protein (HSP20) family. This protein can be inducted by 17-beta-estradiol, and is predominantly expressed in skeletal muscle and heat, mainly located in the cytoplasm and nucleus. HSPB8 usually exists in monomer, it can interact with HSPB1 and DNAJB6. HSPB8 displays temperature-dependent chaperone activity, appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease.
Abbreviation
HSPB8
Synonyms
Alpha-crystallin C chain; CRYAC; E2-induced gene 1 protein; E2IG1; HSP22; HSPB8; Heat shock protein beta-8; HspB8; Protein kinase H11; Small stress protein-like protein HSP22
UniProt
Q9UJY1
Accession Number
Q9UJY1
Expression System
E.coli
Tag
C-His
Sequence
Met 1-Thr196
Field of Research
Signal Transduction; Neuroscience
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
22.7 kDa
Observed Molecular Weight
23 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 5mM EDTA, pH 7.4.
Species
Human
Available Sizes
Documents
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