Recombinant Human GDF11/BMP-11 Protein
Product Specifications
Background
Growth/differentiation factor 11 (GDF-11) is a secreted protein, which belongs to the transforming growth factor beta superfamily. GDF-11 controls anterior-posterior patterning by regulating the expression of Hox genes. The secreted signal acts globally to specify positional identity along the anterior/posterior axis during development. GDF11 has been shown to suppress neurogenesis through a pathway similar to that of myostatin, including stopping the progenitor cell-cycle during G-phase. The similarities between GDF11 and myostatin imply a likelihood that the same regulatory mechanisms are used to control tissue size during both muscular and neural development.
Abbreviation
GDF11; BMP-11
Synonyms
BMP-11; Bone morphogenetic protein 11; GDF-11; Growth/differentiation factor 11
UniProt
O95390
Accession Number
O95390
Expression System
HEK293 Cells
Tag
None
Sequence
Asn299-Ser407
Field of Research
Signal Transduction; Cell biology; Neuroscience
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
12.5 kDa
Observed Molecular Weight
13-20 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 50% glycerol, pH 7.4.
Species
Human
Available Sizes
Curated Selection
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