Recombinant Human GCDH Protein (His Tag)
Product Specifications
Background
Glutaryl-CoA Dehydrogenase Mitochondrial (GCDH) is an enzyme that acts upon glutaryl-coenzyme A, creating crotonyl-coenzyme A. It plays a role in the metabolism of lysine, hydroxylysine and tryptophan. It uses electron transfer flavoprotein as its electron acceptor. Isoform Short is inactive Glutaryl-CoA and electron-transfer flavoprotein to (E) -but-2-enoyl-CoA, CO2 and reduced electron-transfer flavoprotein. A defect in this enzyme is associated with neurological condition glutaric acidemia type 1 and cause a progressive form of early-onset generalized dystonia.
Abbreviation
GCDH
Synonyms
GCD; GCDH; Glutaryl-CoA Dehydrogenase Mitochondrial
UniProt
Q92947
Accession Number
Q92947
Expression System
E.coli
Tag
N-His
Sequence
Arg45-Lys438
Field of Research
Signal Transduction; Tags & Cell Markers; Cancer; metabolism
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
45.0 kDa
Observed Molecular Weight
41 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM HEPES, 150mM NaCl, pH 7.4.
Species
Human
Available Sizes
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