Recombinant Human Glucagon/GCG Protein (His Tag)
Product Specifications
Background
Glucagon is a secreted protein and belongs to the glucagon family. Glucagon can be cleved into 8 chains, playing an important role in initiating and maintaining hyperglycemic conditions in diabetes. Glucagon can regulates blood glucose by decreasing glycolysis and increasing gluconeogenesis. In addition, Glucagon is involved in initiating and maintaining hyperglycemic conditions in diabetes. Glucagon release is stimulated by hypoglycemia and inhibited by hyperglycemia, insulin, and somatostatin. In the glucagon antagonist, His-53 and Phe-58 are missing. This antagonist has been successfully utilized to reduce glucose concentration in vivo.
Abbreviation
Glucagon; GCG
Synonyms
GCG; GLP-1; GLP-2; GRPP; Glicentin; Glicentin-Related Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Glucagon-like Peptide 1; Incretin Hormone; OXM; OXY; Oxyntomodulin
UniProt
P01275
Accession Number
P01275
Expression System
HEK293 Cells
Tag
C-His
Sequence
Arg21-Lys180
Field of Research
Signal Transduction; Cancer; Developmental Biology; metabolism; Stem cells
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
18.6 kDa
Observed Molecular Weight
19 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 200mM NaCl, 1mM DTT, 50% Glycerol, pH 8.0.
Species
Human
Available Sizes
Documents
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