Recombinant Human GFRRA2 Protein ((Fc & His Tag)

Product Specifications

Background

GDNF family receptor alpha-2 is a glycosylphosphatidylinosito l (GPI) -linked cell surface receptor. It is part of the GDNF receptor family. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GFRA2 mediates the NRTN-induced autophosphorylation and activation of the RET receptor. It also able to mediate GDNF signaling through the RET tyrosine kinase receptor. It acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1.

Abbreviation

GFRRA2

Synonyms

GDNF Family Receptor Alpha-2; GDNF Receptor Alpha-2; GDNF Receptor Beta; GDNFR-Alpha-2; GDNFR-Beta; GDNFRB; GFR-Alpha-2; GFRA2; NRTNR-Alpha; NTNR-Alpha; Neurturin Receptor Alpha; RET Ligand 2; RETL2; TGF-Beta-Related Neurotrophic Factor Receptor 2; TRNR2

UniProt

O00451

Accession Number

O00451

Expression System

HEK293 Cells

Tag

C-Fc-His

Sequence

Ser22-Ser441

Field of Research

Neuroscience

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.