Recombinant Human Gankyrin/PSDM10 Protein
Product Specifications
Background
Gankyrin is a multicatalytic proteinase oncoprotein consists of 7 ankyrin repeats. Gankyrin overexpressed in most hepatocellular carcinomas. Gankyrin is involved in theregulation of the phosphorylation of the retinoblastoma protein by CDK4 to enhance the ubiquitinylation of p53 by MDM2. Gankyrin is also involved in progression of esophageal squamous cell carcinoma. Gankyrin plays an oncogenic role especially in early stages of human epatocarcinogenesis.
Abbreviation
Gankyrin; PSDM10
Synonyms
26S Proteasome Non-ATPase Regulatory Subunit 10;26S Proteasome Regulatory Subunit p28; Gankyrin; PSMD10; p28 (GANK)
UniProt
O75832
Accession Number
O75832
Expression System
E.coli
Tag
None
Sequence
Met 1-Gly226
Field of Research
Cell biology; Cancer
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
24.4 kDa
Observed Molecular Weight
26 kDa
Formulation
Supplied as a 0.2 μm filtered solution of PBS, 10% Glycerol, pH 7.4.
Species
Human
Available Sizes
Documents
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