Recombinant Human GADD45β/GADD45B Protein (His Tag)

Product Specifications

Background

Growth Arrest and DNA Damage-Inducible Protein GADD45 β (GADD45B) is a member of the GADD45 family. GADD45B has been shown to interact with MAP3K4, ASK1, MAP2K7, and GADD45GIP1. GADD45B is involved in the regulation of growth and apoptosis. GADD45B reacts to environmental stresses by mediating activation of stress-responsive MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. In addition, GADD45B participates in the down-regulation of hepatocellular carcinoma (HCC) . It may serve as a possible therapeutic target.

Abbreviation

GADD45β; GADD45B

Synonyms

GADD45B; Growth Arrest and DNA Damage-Inducible Protein GADD45 Beta; MYD118; Myeloid Differentiation Primary Response Protein MyD118; Negative Growth Regulatory Protein MyD118

UniProt

O75293

Accession Number

O75293

Expression System

E.coli

Tag

N-His

Sequence

Met 1-Arg160

Field of Research

Signal Transduction; Cell biology; Cancer; epigenetics and nuclear signal; immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.