Recombinant Human Fumarase/FH Protein
Product Specifications
Background
Fumarase is an enzyme that catalyze the reversible hydration/dehydration of fumarate to S-malate and is involved in the tricarboxylic acid or Krebs cycle. Fumarase exists in both form, cytosolic formand N-terminal extend mitochondrial form. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension is the same form as in the cytoplasm. Fumarase is thought to act as a tumor suppressor, which deficiency can lead to progressive encephalopathy, cerebral atrophy and development delay.
Abbreviation
Fumarase; FH
Synonyms
FH; FMRD; Fumarase; Fumarate Hydratase Mitochondrial; HLRCC; LRCC; MCL; MCUL1
UniProt
P07954
Accession Number
P07954
Expression System
E.coli
Tag
None
Sequence
Ala45-Lys510
Field of Research
Signal Transduction; Cancer; metabolism
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
50.2 kDa
Observed Molecular Weight
45 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, pH 8.0.
Species
Human
Available Sizes
Documents
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