Recombinant Human CD32a/FCGR2A Protein (H131, His Tag)

Human FcγRs are divided into three classes designated FcγRI (CD64) ; FcγRII (CD32) ; and FcγRIII (CD16) ; which generate multiple isoforms; are recognized. The activating- type receptor either has or associates non-covalently with an accessory subunit that has an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. FcγRI binds IgG with high affinity and functions during early immune responses; whereas FcγRII and RIII are low affinity receptors that recognize IgG as aggregates surrounding multivalent antigens during late immune responses.Human CD32; also known as Low affinity immunoglobulin γ Fc region receptor II-a (IgG Fc receptor II-a) ; FcγRII A or FCGR2A Protein; is expressed on cells of both myeloid and lymphoid lineages as well as on cells of non-hematopoietic origin. Associated with an ITAM-bearing adapter subunit; FcRγ; CD32a (FcγRII A) delivers an activating signal upon ligand binding; and results in the initiation of inflammatory responses including cytolysis; phagocytosis; degranulation; and cytokine production. The responses can be modulated by signals from the co-expressed inhibitory receptors such as Fcγ RII B; and the strength of the signal is dependent on the ratio of expression of the activating and inhibitory receptors.

CD32; CD32A; CDw32; FCG2; FCGR2 ; FCGR2A; FCGR2A1; Fc gamma RIIA; Fc-gamma RII-a; Fc-gamma-RIIa; FcGR; FcRII-a; IGFR2; IgG Fc receptor II-a; Low affinity immunoglobulin gamma Fc region receptor II-a

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.