Recombinant Human FAS/TNFRSF6 Protein (Fc Tag)
Product Specifications
Background
FAS (TNFRSF6) is a receptor and contains three TNFR-Cys repeats and one death domain. It has been shown that FAS is involved in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. FADD (adapter molecule) recruits caspase-8 to the activated receptor, the resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases mediating apoptosis. FAS-mediated apoptosis may play a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both.
Abbreviation
FAS; TNFRSF6
Synonyms
APT1; Apo-1 antigen; Apoptosis-mediating surface antigen FAS; FAS1; FASLG receptor; TNFRSF6 and FAS; Tumor necrosis factor receptor superfamily member 6
UniProt
P25445
Accession Number
P25445
Expression System
HEK293 Cells
Tag
C-Fc
Sequence
Gln26-Asn173
Field of Research
Cell biology; immunology
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
44.6 kDa
Observed Molecular Weight
60 kDa
Formulation
Supplied as a 0.2 μm filtered solution of PBS, pH7.4.
Species
Human
Available Sizes
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