Recombinant Human MAN1B1 Protein (His Tag)
Product Specifications
Background
Endoplasmic Reticulum Mannosyl-Oligosaccharide 1,2-α-Mannosidase (MAN1B1) belongs to the glycosyl hydrolase 47 family. MAB1B1 is a single-pass type II membrane protein and widely expressed in many tissues. MAB1B1 is involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. MAB1B1 can be inhibited by both 1-deoxymannojirimycin (dMNJ) and kifunensine. Defects in MAN1B1 are the cause of mental retardation autosomal recessive type 15 (MRT15) . Mental retardation is characterized by significantly below average general intellectual functioning, it is also associated with impairments in adaptative behavior and manifested during the developmental period.
Abbreviation
MAN1B1
Synonyms
2-Alpha-Mannosidase;2-Mannosidase; ER Alpha-1; ER Mannosidase 1; ERMan1; Endoplasmic Reticulum Mannosyl-Oligosaccharide 1; MAN1B1; Man9GlcNAc2-Specific-Processing Alpha-Mannosidase; Mannosidase Alpha Class 1B Member 1
UniProt
Q9UKM7
Accession Number
Q9UKM7
Expression System
HEK293 Cells
Tag
C-His
Sequence
Asp106-Ala699
Field of Research
Tags & Cell Markers
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
68.7 kDa
Observed Molecular Weight
58-80 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 50mM Tris-HCl,10mM reduced Glutathione, pH 8.0.
Species
Human
Available Sizes
Documents
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