Recombinant Human Ephrin-A1/EFNA1 Protein (His Tag)

Product Specifications

Background

Ephrin-A1 is a member of the A-type ephrin family of cell surface proteins that function as ligands for the A-type Eph receptor tyrosine kinase family. Ephrin-A1 can be induced by TNF and IL1B. Its expression levels can be down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells. Soluble Ephrin-A1 is necessary for the transformation of HeLa and SK-BR3 cells and participates in the relocalization of EPHA2 away from sites of cell-cell contact during transformation. Ephrin-A1 plays an important role in angiogenesis and tumor neovascularization.

Abbreviation

Ephrin-A1; EFNA1

Synonyms

EFNA1; EPH-Related Receptor Tyrosine Kinase Ligand 1; EPLG1; Ephrin-A1; Immediate Early Response Protein B61; LERK-1; LERK1; TNF Alpha-Induced Protein 4; TNFAIP4; Tumor Necrosis Factor Alpha-Induced Protein 4

UniProt

P20827

Accession Number

AAH32698.1

Expression System

HEK293 Cells

Tag

C-His

Sequence

Asp19-Ser182

Field of Research

Signal Transduction; Cardiovascular; Neuroscience

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.