Recombinant Human PI3/Elafin Protein (His Tag)
Product Specifications
Background
Elafin is a secreted protein. Elafin consists of two domains: the transglutaminase substrate domain (cementoin moiety) and the elastase inhibitor domain. The transglutaminase substrate domain serves as an anchor to localize Elafin covalently to specific sites on extracellular matrix proteins. It is shown that Elafin can be used as a biomarker for graft versus host disease of the skin. Elafin is expressed in the skin during wound healing through activation of the epidermal growth factor receptor. Elafin may prevent elastase-mediated tissue proteolysis.
Abbreviation
PI3; Elafin
Synonyms
ESI; Elafin; Elastase-Specific Inhibitor; PI-3; PI3; Peptidase Inhibitor 3; Protease inhibitor WAP3; SKALP; Skin-Derived Antileukoproteinase; WAP Four-Disulfide Core Domain Protein 14; WAP3; WFDC14
UniProt
P19957
Accession Number
P19957
Expression System
HEK293 Cells
Tag
C-His
Sequence
Ala23-Gln117
Field of Research
Microbiology; Cell biology; Cancer; immunology
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
11.0 kDa
Observed Molecular Weight
13-18 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 7.5.
Species
Human
Available Sizes
Curated Selection
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