Recombinant Human 4E-BP1/EIF4EBP1 Protein (His Tag)
Product Specifications
Background
Eukaryotic Translation Initiation Factor 4E-Binding Protein 1 (4EBP1) is a number of the eIF4E-binding protein family. 4EBP1 regulates eIF4E activity by preventing its assembly into the eIF4F complex. 4EBP1 mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. Non-phosphorylated 4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E. 4EBP1 is phosphorylated in response to various signals including insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. 4EBP1 has a role in progression of breast neoplasms through cell signaling.
Abbreviation
4E-BP1; EIF4EBP1
Synonyms
4E-BP1;4EBP1; BP-1; EIF4EBP1; Eukaryotic Translation Initiation Factor 4E-Binding Protein 1; PHAS-I; Phosphorylated Heat- and Acid-Stable Protein Regulated by Insulin 1; eIF4E-Binding Protein 1
UniProt
Q13541
Accession Number
Q13541
Expression System
E.coli
Tag
N-His
Sequence
Met 1-Ile118
Field of Research
Epigenetics and nuclear signal; metabolism
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 90 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/dxiqqp
Product MSDS
https://789.bio/eb/HejfXP
Calculated Molecular Weight
14.7 kDa
Observed Molecular Weight
17 kDa
Species
Human
Available Sizes
Curated Selection
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