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Recombinant Human DTD1 Protein (His Tag)

Product Specifications

Background

D-tyrosyl-tRNA (Tyr) deacylase 1 (DTD1) belongs to the DTD family, and expressed in many adult and fetal tissues such as testis, ovary, spleen in adult and fetal brain. It is a nucleus and cytoplasm located protein, and is preferentially phosphorylated in cells arrested early in S phase. DTD1 is an ATPase involved in DNA replication, it may facilitate loading of CDC45 onto pre-replication complexes. The protein may hydrolyze D-tyrosyl-tRNA (Tyr) into D-tyrosine and free tRNA (Tyr), a possible defense mechanism against a harmful effect of D-tyrosine.

Abbreviation

DTD1

Synonyms

C20orf88; D-tyrosyl-tRNA (Tyr) deacylase 1; DNA-unwinding element-binding protein B; DTD1; DUE-B; DUEB; HARS2; Histidyl-tRNA synthase-related

UniProt

Q8TEA8

Accession Number

Q8TEA8

Expression System

HEK293 Cells

Tag

C-His

Sequence

Met 1-Pro209

Field of Research

Signal Transduction; epigenetics and nuclear signal; metabolism

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

24.5 kDa

Observed Molecular Weight

30 kDa

Formulation

Supplied as a 0.2 μm filtered solution of PBS, pH7.4.

Species

Human

Available Sizes

Curated Selection

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