Recombinant Human HSP40/DNAJB1 Protein (His Tag)

Product Specifications

Background

DnaJ Homolog Subfamily B Member 1 (DNAJB1) is a member of the heat shock protein family. Heat shock proteins (HSPs) are a highly conserved family of stress response proteins. HSPs function primarily as molecular chaperones, facilitating the folding of other cellular proteins, preventing protein aggregation, or targeting improperly folded proteins to specific degradative pathways. DNAJB1 regulates cellular processes by aiding in the folding, transport and assembly. DNAJB1 contains a J-domain which controls interaction with the ATPase domain of DnaK. DNAJB1 interacts with HSP70 and can stimulate its ATPase activity. In addition, DNAJB1 stimulates the association between HSC70 and HIP.

Abbreviation

HSP40; DNAJB1

Synonyms

DNAJ1; DNAJB1; DnaJ Homolog Subfamily B Member 1; DnaJ Protein Homolog 1; HDJ1; HSP40; HSPF1; Heat Shock 40 kDa Protein 1; Heat Shock Protein 40; Human DnaJ Protein 1; hDj-1

UniProt

P25685

Accession Number

P25685

Expression System

E.coli

Tag

C-His

Sequence

Gly2-Ile340

Field of Research

Signal Transduction

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.