Recombinant Human DFFA Protein (His Tag)
Product Specifications
Background
DNA Fragmentation Factor Subunit Alpha (DFFA) . DFFA exists as a heterodimer (DFF) with DFFB. DFF is activated once DFFA is cleaved by Caspase-3. The cleaved fragments of DFFA detach from DFFB (the active component of DFF), which in turn triggers DNA fragmentation as well as chromatin condensation during apoptosis. A reduced level of DFFA detected in ovarian endometriosis may be a part of an apoptosis-resistant mechanism enhancing the disease progression.
Abbreviation
DFFA
Synonyms
DFF-45; DFF1; DFF45; DFFA; DNA Fragmentation Factor 45 kDa Subunit; DNA Fragmentation Factor Subunit Alpha; H13; ICAD; Inhibitor of CAD
UniProt
O00273
Accession Number
AAH07721.1
Expression System
E.coli
Tag
N-His
Sequence
Met 1-Thr331
Field of Research
Cell biology; Cancer; epigenetics and nuclear signal; metabolism
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 85 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
38.7 kDa
Observed Molecular Weight
40-50 kDa
Formulation
Supplied as a 0.2 μm filtered solution of PBS, pH7.4.
Species
Human
Available Sizes
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