Recombinant Human Diamine Oxidase/AOC1 Protein (His Tag)
Product Specifications
Background
Amiloride-sensitive amine oxidase (AOC1) belongs to the copper/topaquinone oxidase family. The protein exists as homodimer by disulfide and mainly located in placenta and kidney. AOC1 catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function. The activity of this protein can be inhibited by amiloride in a competitive manner. It is inhibited by amiloride, a diuretic that acts by closing epithelial sodium ion channels.
Abbreviation
Diamine Oxidase; AOC1
Synonyms
ABP1; AOC1; Amiloride-binding protein 1; Amiloride-sensitive amine oxidase [copper-containing]; Amine oxidase copper domain-containing protein 1; DAO; DAO1; Diamine oxidase; Histaminase; KAO; Kidney amine oxidase
UniProt
P19801
Accession Number
AAH14093.1
Expression System
HEK293 Cells
Tag
C-His
Sequence
Glu20-Val751
Field of Research
Cell biology
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
84.4 kDa
Observed Molecular Weight
90 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH 7.5.
Species
Human
Available Sizes
Curated Selection
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