Recombinant Human Cystatin C/CST3 Protein (Human Cells, His Tag)

Product Specifications

Background

Cystatin C is a member of family 2 of the cystatin superfamily. It is ubiquitous in human tissues and body fluids and mainly used as a biomarker of kidney function. Cystatin C inhibits many cysteine proteases such as papain and Cathepsins B; H; K; L and S. As an inhibitor of cysteine proteinases; Cystatin C is thought to serve an important physiological role as a local regulator of this enzyme activity. Recently; it has been studied for its role in predicting new-onset or deteriorating cardiovascular disease. It also seems to play a role in brain disorders involving amyloid (a specific type of protein deposition) ; such as Alzheimer's disease.

Abbreviation

Cystatin C; CST3

Synonyms

CST3; Cystatin-3; Cystatin-C; Gamma-trace; Neuroendocrine basic polypeptide; Post-gamma-globulin

UniProt

P01034

Accession Number

P01034

Expression System

HEK293 Cells

Tag

C-His

Sequence

Ser27-Ala146

Field of Research

Tags & Cell Markers; Cell biology; Cardiovascular; Stem cells

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

14.4 kDa

Observed Molecular Weight

15-18 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 500mM NaCl, 0.01% Tween 80, 1mM EDTA, 50% Glycerol, pH 8.0.

Species

Human

Available Sizes

Documents

Product Datasheet

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