Recombinant Human Cystathionine γ-Lyase/CTH Protein
Product Specifications
Background
Cystathionine Gamma-Lyase (CTH) belongs to the trans-sulfuration enzymes family. CTH exists as a homotetramer and interacts with CALM in a calcium-dependent manner. CTH breaks down cystathionine into cysteine, ammonia and 2-oxobutanoate. CTH catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine and has broad substrate specificity. Defects in CTH will lead to cystathioninuria, which is an autosomal recessive phenotype characterized by abnormal accumulation of plasma cystathionine.
Abbreviation
Cystathionine γ-Lyase; CTH
Synonyms
CTH; Cystathionine Gamma-Lyase; Cysteine-Protein Sulfhydrase; Gamma-Cystathionase
UniProt
P32929
Accession Number
P32929
Expression System
E.coli
Tag
None
Sequence
Met 1-Ser405
Field of Research
Signal Transduction; Cancer; metabolism
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 85 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
44.7 kDa
Observed Molecular Weight
38-50 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 8% Sucrose, 0.05% Tween 80, pH8.0.
Species
Human
Available Sizes
Documents
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