Recombinant Human CXCL7/NAP-2 Protein

Human Chemokine (C-X-C motif) Ligand 7 (CXCL7) ; also known as neutrophil activating peptide 2 (NAP-2) ; is a member of the CXC chemokines containing an ELR domain (Glu-Leu-Arg tripeptide motif) . Similar to other ELR domain containing CXC chemokines; such as IL-8 and the GRO proteins; CXCL7 binds CXCR2; chemoattracts and activates neutrophils. CXCL7; Connective Tissue Activating Protein III (CTAPIII) and βthrombogulin (βTG) ; are proteolytically processed carboxylterminal fragments of platelet basic protein (PBP) which is found in the alphagranules of human platelets. Although CTAPIII; βTG; and PBP represent amino-terminal extended variants of NAP2 and possess the same CXC chemokine domains; these proteins do not exhibit CXCL7/NAP2 activity. CXCL7 induces cell migration through the G-protein-linked receptor CXCR-2.

C-X-C Motif Chemokine 7; CTAP3; CXCL7; LDGF; Leukocyte-Derived Growth Factor; MDGFSmall-Inducible Cytokine B7; Macrophage-Derived Growth Factor; PBP; PPBP; Platelet Basic Protein; SCYB7; TGB1; THBGB1

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.