Recombinant Human CX3CL1/Fractalkine Protein (His Tag)

Product Specifications

Background

Human Fractalkine (CX3CL1) is a member of the CX3C family of chemokines. Human Fractalkine contains both chemokine and mucin domain. The soluble form of Fractalkine is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane bound form of Fractalkine promotes leukocytes adhesion to endothelial cells. Fractalkine regulates leukocyte adhesion and migration processes at the endothelium and binds to CX3CR1. Natural Human Fractalkine is produced as a long protein (373-amino acid) . The mucin-like stalk permits it to bind to the cell surface.

Abbreviation

CX3CL1; Fractalkine

Synonyms

C-X3-C Motif Chemokine 1; CX3C Membrane-Anchored Chemokine; CX3CL1; FKN; Fractalkine; NTT; Neurotactin; SCYD1; Small-Inducible Cytokine D1

UniProt

P78423

Accession Number

P78423

Expression System

HEK293 Cells

Tag

C-His

Sequence

Gln25-Arg339

Field of Research

Cardiovascular; immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.