Recombinant Human Cornulin/CRNN Protein (His Tag)

Cornulin is a member of the fused gene family of molecular chaperones. Human Cornulin contains N-terminus EF-hand domains and Ca2+ binding domains, and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. Cornulin involves in the mucosal/epithelial immune response and epidermal differentiation. Cornulin is a survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA) -induced apoptotic cell death and release of calcium. When Cornulin is overexpressed in oral squamous carcinoma cell lines, it regulates negatively cell proliferation by the induction of G1 arrest.

53 kDa Putative Calcium-Binding Protein;53 kDa Squamous Epithelial-Induced Stress Protein;58 kDa Heat Shock Protein; C1orf10; CRNN; Cornulin; DRC1; PDRC1; SEP53; Squamous Epithelial Heat Shock Protein 53; Tumor-Related Protein

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.