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Berberrubine (chloride)

Berberrubine chloride is an orally active metabolite of berberine. Berberrubine chloride alleviates mucosal lesions and inflammation in mouse colitis models. Berberrubine chloride has anti-inflammatory, anti-tumor, and antiviral activities[1][1][3].

Product Specifications

CAS Number

15401-69-1

UNSPSC

12352005

Hazard Statement

H302

Target

Drug Metabolite; HIV; Interleukin Related

Type

Natural Products

Related Pathways

Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/berberrubine-chloride.html

Purity

99.28

Solubility

DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : 2 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

COC1=C(O)C2=C[N+]3=C(C(C(CC3)=C4)=CC5=C4OCO5)C=C2C=C1.[Cl-]

Molecular Formula

C19H16ClNO4

Molecular Weight

357.79

Precautions

H302

References & Citations

[1]Yu XT, et al. Berberrubine attenuates mucosal lesions and inflammation in dextran sodium sulfate-induced colitis in mice. PLoS One. 2018 Mar 14;13 (3) :e0194069.|[2]Lo CY, et al. Synthesis and anticancer activity of a novel series of 9-O-substituted berberine derivatives: a lipophilic substitute role. Bioorg Med Chem Lett. 2013 Jan 1;23 (1) :305-9.|[3]Bodiwala HS, et al. Synthesis of 9-substituted derivatives of berberine as anti-HIV agents. Eur J Med Chem. 2011 Apr;46 (4) :1045-9.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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