Recombinant Human CLIC1 Protein (His Tag)

Product Specifications

Background

Chloride Intracellular Channel Protein 1 (CLIC1) belongs to the Chloride Channel CLIC family and contains one GST C-terminal domain. CLIC1 can be expressed in various cell types, but it is especially prominent in the heart, placenta, liver, kidney, and pancreas. CLIC1 can insert into membranes and form chloride ion channels. The channel activity depends on the pH. CLIC1 membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. CLIC1 is also involved in the regulation of the cell cycle.

Abbreviation

CLIC1

Synonyms

CLIC1; Chloride Channel ABP; Chloride Intracellular Channel Protein 1; G6; NCC27; Nuclear Chloride Ion Channel 27; Regulatory Nuclear Chloride Ion Channel Protein; hRNCC

UniProt

O00299

Accession Number

O00299

Expression System

E.coli

Tag

N-His

Sequence

Met 1-Lys241

Field of Research

Signal Transduction; Cancer; metabolism

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.