Recombinant Human CCL5/RANTES Protein

Product Specifications

Background

Human Chemokine (C-C Motif) Ligand 5 (CCL5) plays an active role in recruiting leukocytes into inflammatory sites. CCL5 is secreted by many cell types at inflammatory sites and it exerts a wide range of activities through the receptors CCR1, CCR3, CCR4, and CCR5. N-Terminal truncated CCL5/RANTES, Met-RANTES, and amino-oxypentane (AOP) -RANTES exhibit antagonist or partial agonist functions on their receptors. CCL5/RANTES attracts different subtypes of leukocytes into inflamed tissue and intervenes in a wide range of allergic and autoimmune diseases.

Abbreviation

CCL5; RANTES

Synonyms

C-C Motif Chemokine 5; CCL5; D17S136E; EoCP; Eosinophil Chemotactic Cytokine; SCYA5; SIS-Delta; Small-Inducible Cytokine A5; T Cell-Specific Protein P228; T-Cell-Specific Protein RANTES; TCP228

UniProt

P13501

Accession Number

P13501

Expression System

E.coli

Tag

None

Sequence

Ser24-Ser91

Field of Research

Cardiovascular; immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.