Recombinant Human CCL11/Eotaxin Protein
Product Specifications
Background
C-C Motif Chemokine 11 (CCL11) is a secreted protein that belongs to the intercrine beta (chemokine CC) family. In response to the presence of allergens, CCL11 selectively recruits eosinophils, a prominent feature of allergic inflammatory reactions. The effects of CCL11 are mediated by its binding to a G-protein-linked receptor known as a chemokine receptor. Chemokine receptors for CCL11 include CCR2, CCR3 and CCR5. However, it has been found that CCL11 has high degree selectivity for its receptor, such that they are inactive on neutrophils and monocytes, which do not express CCR3.
Abbreviation
CCL11; Eotaxin
Synonyms
C-C Motif Chemokine 11; CCL11; Eosinophil Chemotactic Protein; Eotaxin; SCYA11; Small-Inducible Cytokine A11
UniProt
P51671
Accession Number
P51671
Expression System
E.coli
Tag
None
Sequence
Gly24-Pro97
Field of Research
Immunology
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/l5kds4
Product MSDS
https://789.bio/eb/Ca5C40
Calculated Molecular Weight
8.6 kDa
Observed Molecular Weight
10 kDa
Species
Human
Available Sizes
Curated Selection
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