Recombinant Human Carbonic Anhydrase 8/CA8 Protein (His Tag)
Product Specifications
Background
Carbonic Anhydrase 8 (CA8) belongs to the alpha-carbonic anhydrase family. Alpha-carbonic anhydrase is a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. Because CA8 has some sequence similarity with other known carbonic anhydrase genes, it was firstly called as CA-related protein. Nevertheless, CA8 does not have a carbonic anhydrase catalytic activity. Defects in CA8 are the cause of cerebellar ataxia mental retardation and dysequilibrium syndrome type 3 (CMARQ3), which is a congenital cerebellar ataxia associated with dysarthia, quadrupedal gait and mild mental retardation.
Abbreviation
Carbonic Anhydrase 8; CA8
Synonyms
CA-VIII; CA8; CALS; CAMRQ3; CARP; Carbonic Anhydrase VIII; Carbonic Anhydrase-Related Protein; MGC120502; MGC99509
UniProt
P35219
Accession Number
P35219
Expression System
E.coli
Tag
C-His
Sequence
Ala2-Gln290
Field of Research
Cancer
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
34.0 kDa
Observed Molecular Weight
40 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 500mM NaCl, 1mM DTT, pH 8.5.
Species
Human
Available Sizes
Documents
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