Recombinant Human Calcitonin/CALCA Protein (His Tag, E. coli)
Product Specifications
Background
Calcitonin is a secreted protein which belongs to the calcitonin family. Calcitonin is cleaved into the following two chains: Calcitonin and Katacalcin. Katacalcin is a potent plasma calcium-lowering peptide. Calcitonin is a 32-amino acid linear polypeptide hormone. Calcitonin acts to reduce blood calcium (Ca2+) ; opposing the effects of parathyroid hormone (PTH) . Its importance in humans has not been as well established as its importance in other animals; as its function is usually not significant in the regulation of normal calcium homeostasis. Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.
Abbreviation
Calcitonin; CALCA
Synonyms
CALC1; CALCA; CCP; Calcitonin; Calcitonin Carboxyl-Terminal Peptide; Katacalcin; PDN-21
UniProt
P01258
Accession Number
P01258
Expression System
E.coli
Tag
C-His
Sequence
Tyr58-Asn141
Field of Research
Signal Transduction; Cardiovascular; Neuroscience; Cancer
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 90 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
10.5 kDa
Observed Molecular Weight
14-20 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 50% Glycerol, pH 7.4.
Species
Human
Available Sizes
Documents
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