Recombinant Human BMPRIA/ALK-3 Protein (Fc & His Tag)

Bone Morphogenetic Protein Receptor Type-1A (BMPR1A) belongs to the TKL Ser/Thr protein kinase family and TGFB receptor subfamily, including the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. BMPR1A is a single-pass type I membrane protein and highly expressed in skeletal muscle. BMPR1A contains one GS domain and one protein protein kinase domain. BMPR1A is necessary for the extracellular matrix depostition by osteoblasts. BMPR1A can activate SMAD transcriptional regulators, binding with ligands. Defects in BMPR1A are a cause of juvenile polyposis syndrome, Cowden disease and hereditary mixed polyposis syndrome 2 (HMPS2) .

10q23del; ACVRLK3; ALK-3; ALK3; Activin Receptor-Like Kinase 3; BMP Type-1A Receptor; BMPR-1A; BMPR1A; Bone Morphogenetic Protein Receptor Type-1A; CD292; SKR5; Serine/Threonine-Protein Kinase Receptor R5

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.