Recombinant Human BMPRIA/ALK-3 Protein (Fc & His Tag)

Product Specifications

Background

Bone Morphogenetic Protein Receptor Type-1A (BMPR1A) belongs to the TKL Ser/Thr protein kinase family and TGFB receptor subfamily, including the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. BMPR1A is a single-pass type I membrane protein and highly expressed in skeletal muscle. BMPR1A contains one GS domain and one protein protein kinase domain. BMPR1A is necessary for the extracellular matrix depostition by osteoblasts. BMPR1A can activate SMAD transcriptional regulators, binding with ligands. Defects in BMPR1A are a cause of juvenile polyposis syndrome, Cowden disease and hereditary mixed polyposis syndrome 2 (HMPS2) .

Abbreviation

BMPRIA; ALK-3

Synonyms

10q23del; ACVRLK3; ALK-3; ALK3; Activin Receptor-Like Kinase 3; BMP Type-1A Receptor; BMPR-1A; BMPR1A; Bone Morphogenetic Protein Receptor Type-1A; CD292; SKR5; Serine/Threonine-Protein Kinase Receptor R5

UniProt

P36894

Accession Number

P36894

Expression System

HEK293 Cells

Tag

C-Fc-His

Sequence

Gln24-Arg152

Field of Research

Signal Transduction; Cardiovascular; Cancer; metabolism; Stem cells

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.