Recombinant Human BPGM Protein (His Tag)
Product Specifications
Background
Bisphosphoglycerate Mutase (BPGM) is a member of the Phosphoglycerate Mutase family and BPG-Dependent PGAM subfamily. BPGM is a multifunctional enzyme. BPGM catalyzes 2,3-DPG synthesis via its synthetase activity, and 2,3-DPG degradation via its phosphatase activity. It also has phosphoglycerate phosphomutase activity. BPGM plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of 2,3-bisphosphoglycerate (2,3-BPG) . Deficiency of BPGM increases the affinity of cells for oxygen and result in hemolytic anemia.
Abbreviation
BPGM
Synonyms
2,3-Bisphosphoglycerate Mutase Erythrocyte;2,3-Bisphosphoglycerate Synthase;2,3-Diphosphoglycerate Mutase; BPG-Dependent PGAM; BPGM; Bisphosphoglycerate Mutase; DPGM
UniProt
P07738
Accession Number
P07738
Expression System
E.coli
Tag
C-His
Sequence
Ser2-Lys259
Field of Research
Signal Transduction; Cardiovascular; Cancer; metabolism
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
31.0 kDa
Observed Molecular Weight
30 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 1mM DTT, pH 8.0.
Species
Human
Available Sizes
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