Recombinant Human BCL-W/BCL2L2 Protein (His Tag)
Product Specifications
Background
Bcl-2-like protein 2 (BCL2L2) belongs to the Bcl-2 family. BCL2L2 is highly expressed in thebrain, spinal cord, testis, pancreas, heart, spleen, and mammary glands. BCL2L2 is a peripheral membrane protein containing three motifs, BH1, BH2 and BH4. The BH4 motif appears to be involved in the anti-apoptotic function. The BH1 and BH2 motifs form a hydrophobic groove which acts as a docking site for the BH3 domain of some pro-apoptotic proteins. BCL2L2 promotes cell survival and blocks dexamethasone-induced apoptosis. Furthermore, BCL2L2 mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.
Abbreviation
BCL-W; BCL2L2
Synonyms
Apoptosis Regulator Bcl-W; BCL2L2; BCLW; Bcl-2-Like Protein 2; Bcl2-L-2; KIAA0271
UniProt
Q92843
Accession Number
AAI13523.1
Expression System
E.coli
Tag
C-His
Sequence
Ala2-Thr172
Field of Research
Cell biology; Cancer
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
19.9 kDa
Observed Molecular Weight
18 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 25mM HEPES, 100mM KCl, 20% Glycerol, pH 7.5.
Species
Human
Available Sizes
Documents
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